Please read the research paper you have been given and then address the following questions in 1000 words (excluding figures and references). This will be marked as detailed below:

1. What hypothesis or research question/s does the paper address? (10 marks)

2. Choose two of the methods or patient trial designs and analyses presented:

a. How do the methods used address the hypothesis/research question? (10 marks)

b. What are the advantages and disadvantages of the methods chosen? (25 marks)

c. What alternative methods/approaches might be used to address the hypothesis, or answer the specific research questions, other than those presented? (25 marks)

d. Are appropriate controls and data analyses used? (20 marks)

3. In general, are the conclusions made, consistent with the data shown? (10 marks)