Early Drug Development 1. Why do we test potential new medicines in healthy volunteers??If testing new medicines in healthy volunteers is such a good idea, why do we sometimes not do it? 2. Why do so many drugs affect the heart rate? 3. Describe how the beneficial effects of an anti-asthmatics drug may be measured. 4. Discuss the benefits of including placebo treatments in the first administration of drug to man. 5. Explain what is meant by the term “surrogate marker”. Describe how you could use surrogate markers to characterise a new anti-psychotic drug.